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The Ups and Downs of Neuroimaging Research

Arch Gen Psychiatry. 2002;59:31-34.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

IN THIS issue of Archives of General Psychiatry, Suhara et al¹ suggest that dopamine (DA) D₂ receptors in the anterior cingulate cortex (ACCX) are significantly reduced in drug-naïve patients with schizophrenia as compared with healthy controls, and that in the same subjects, D₂ binding in that region correlates negatively with positive symptom scores on the Brief Psychiatric Rating Scale. This was based on positron emission tomography (PET) measurements of the "binding potential" (BP) of D₂ receptors using the positron-emitting D₂ (and D₃ ) receptor radioligand [¹¹C] FLB 457. Binding potential is a common outcome measure that is widely used as a surrogate of B_max (receptor density) but is influenced by several factors, including intrasynaptic DA concentration. In fact, the BP measurement carried out by PET was assumed to be a conglomerate of receptor parameters (not directly measured), including the absolute D₂ DA B_max in the brain, a free . . . [Full Text of this Article]

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