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Almost a third of patients with depression fail to respond to existing treatments, and new treatments are required. Epidemiological evidence about fish intake¹ and blood levels of the relevant fatty acids^2-4 suggests that increased intakes of 3 fatty acids such as eicosapentaenoic acid (EPA) may be helpful. A mixture of EPA and docosahexaenoic acid has been reported to improve depression and the course of illness in bipolar disorder,⁵ but to date, there are no reports of treatment of unipolar depression using this approach.

Report of a Case

We report the case of a 21-year-old male student with a 7-year history of unremitting depressive symptoms. At age 19 years, pharmacotherapy was commenced owing to increasing illness severity, with prominent low self-esteem, insomnia, sadness, inner tension, poor appetite, poor concentration, increasing social phobia, lethargy, pessimistic thoughts, and suicidal thoughts. During the following year there was no response to a variety of antidepressants, hypnotics, and antipsychotic medication; . . . [Full Text of this Article]

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

An Integrative Approach to Depression: Part 2--Assessment and Treatment
Zuess
Complementary Health Practice Review 2003;8:99-115.
ABSTRACT