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The Role of Hypothalamic-Pituitary-Adrenal Axis Dysfunction in the Attenuated Growth Hormone Response in Adolescents With Familial Loading for Affective Disorder
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Birmaher et al1 separated adolescents
into those at high and low risk for affective disorders on the basis of family
history and have demonstrated that those at high risk have a relatively attenuated
growth hormone (GH) response to GH–releasing hormone (GHRH). We propose
that rather than being a "trait marker for depression," these data reflect
hypothalamic-pituitary-adrenal axis dysfunction that has been demonstrated
in patients with high familial loading for affective disorders.2
This view is also supported by preliminary evidence that variations in steroid
function, particularly dehydroepiandrosterone levels, predict subsequent depression
in adolescents.3
Birmaher et al remind us that cortisol inhibits GH release from the
pituitary gland, and while they neither report how and when cortisol was assayed
nor cortisol levels in the 2 groups, the authors report that "no significant
correlations were found between any GH variables and cortisol secretion."
We contend that exactly what measurement was used in this . . . [Full Text of this Article]
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
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Psychosom. Med. 2004;66:349-355.
ABSTRACT
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