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Juvenile-Onset Major Depression Includes Childhood- and Adolescent-Onset Depression and May Be Heterogeneous
Arch Gen Psychiatry. 2002;59:223-224.
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| Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings. |
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IN CONTRAST to the debates of the late 1970s, when large-scale epidemiologic
studies, family genetic studies, and the Dunedin Multidisciplinary Health
and Development Study1 were initiated, it is
now well established that major depressive disorder (MDD) is a disorder that
usually begins in adolescence or early adulthood. It is also clear that prepubertal-onset
MDD is uncommon and that girls are at a higher risk than boys after puberty,
but not before.2-4
Family genetic studies have explored the relationship between age at onset
of MDD and familial loading. The hypothesis was that patients with MDD that
began early (at that time, it was uncertain what was considered early) would
have the highest number of biological relatives affected. The family studies
confirmed the hypothesis that the earlier the age at onset (especially an
onset before age 20 years), the higher the familial loading and specificity
of familial transmission.5 In the late 1980s,
. . . [Full Text of this Article]
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Arch Gen Psychiatry. 2002;59(3):215-222.
ABSTRACT
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