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In the November 2000 issue of the ARCHIVES, Meston and Frohlich¹ provided a review of the past and current literature on the neurobiology of sexual function. We would like to add some facts about luteinizing hormone–releasing hormone (LH-RH) agonists. Experiences with LH-RH agonists have suggested that they might also be helpful in the treatment of paraphilias, especially in connection with sexual offending. Luteinizing hormone–releasing hormone agonists inhibit the production of testosterone by overwhelming the pulsatile stimulation of the pituitary gland by constant stimulation.

Most previous studies concerning the effects of LH-RH agonists in men with paraphilia were mainly case reports.^2-5 In 1998, Rösler and Witztum⁶ provided an open uncontrolled study treating 30 men with paraphilias with triptorelin pamoate. Episodes of deviant sexual behavior were reduced, and the number of deviant sexual fantasies diminished during therapy. Side effects included persistant hot flashes, decreased growth of facial and body hair, asthenia, and . . . [Full Text of this Article]

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