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What Is Happening in the Schizophrenic Brain?

Daniel R. Weinberger, MD; Robert K. McClure, MD

Arch Gen Psychiatry. 2002;59:553-558.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

In an era of dramatic discoveries in neuroscience and genetics, it is likely that many popular theories and formulations about mental illness will need to be revised, if not discarded. The "neurodevelopmental hypothesis" is one of the popular theories about the origins of schizophrenia, which posits that abnormalities of early brain development increase risk for the subsequent emergence of the clinical syndrome.^1-3 An early piece of evidence in support of this hypothesis was the apparent lack of progression of cerebral ventricular enlargement observed with computed tomography during illness.^4-9 An important assumption of the neurodevelopmental hypothesis is that the putative primary pathologic condition of the brain is a reflection of abnormalities of early development. The neurodevelopmental hypothesis thus assumes that developmental neuropathologic conditions should arrest early in life and not continue to progress. The computed tomography results showing no apparent progression seemed consistent . . . [Full Text of this Article]

From the Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Md.

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