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Several controlled studies suggest that high-frequency repetitive transcranial magnetic stimulation is associated with antidepressant effects.^1-5 Interestingly enough, the 2 studies investigating relatively older depressed patients^{2, 5} demonstrated a lesser effect than did the studies performed in a younger population. This is in stark contrast to the finding that another method of brain stimulation, electroconvulsive therapy, is somewhat more effective in older patients.⁶ Figiel et al² assumed that this finding could be associated with the structural brain changes that are often found in older depressed patients.⁷ Lai and colleagues⁸ were recently able to demonstrate an orbitofrontal cortex volume reduction in geriatric depressed patients. Kozel et al⁹ investigated the relationship of the distance between the stimulating coil and the cortex to age and antidepressant response and were not able to find a significant correlation in 12 patients with a mean age of 42 years; however, they demonstrated that treatment responders were younger and . . . [Full Text of this Article]

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Simple Metric For Scaling Motor Threshold Based on Scalp-Cortex Distance: Application to Studies Using Transcranial Magnetic Stimulation
Stokes et al.
J. Neurophysiol. 2005;94:4520-4527.
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