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	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Gorman et al¹ claim "evidence for a central fear mechanism" in panic disorder (PD). They state the following in their abstract:

Background: Inhalation of carbon dioxide (CO₂) has been shown to produce more anxiety in patients with panic disorder (PD) than in healthy comparison subjects or patients with most other psychiatric illnesses tested, although premenstrual dysphoric disorder (PMDD) may be an exception. Several reasons have been proposed to explain CO₂ breathing effects in PD. We examined differences in respiratory response to CO₂ breathing in 4 groups to address these issues.
Methods: Patients with PD (n = 52), healthy controls (n = 32), patients with PMDD (n = 10), and patients with major depression without panic (n = 21) were asked to breathe 5% and 7% CO₂. Continuous measures of respiratory physiological indices were made.
Results: Carbon dioxide breathing produced the expected increases in all 4 respiratory variables measured. . . . [Full Text of this Article]

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