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Because of its location in a region previously linked to schizophrenia (22q),¹ and its critical involvement in the homeostasis of dopamine metabolism in brain regions relevant for schizophrenia, such as the dorsolateral prefrontal cortex (DLPFC),^2-3 it was hypothesized that allelic variants of the catechol-O-methyltransferase (COMT) gene may modulate the risk for this disorder. Recently, in accordance with this hypothesis, an allele coding for an isoform with high enzymatic activity of the COMT (Val allele of the Val-108/158-Met polymorphism) was associated or linked to schizophrenia.⁴ Moreover, it was shown in that study, part of the variance for the Wisconsin Card Sorting Test (WCST; a neuropsychological test that maps mainly into the DLPFC), performance was explained by the Val-108/158-Met polymorphism, both in schizophrenic patients and in healthy controls, where subjects carrying 1 or 2 copies of the Val allele performed significantly worse on . . . [Full Text of this Article]

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