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Both evidence and common sense suggest that the earlier the treatment of schizophrenia begins, optimally even before the onset of psychosis, the more rapid the immediate recovery and the better the overall outcome. Therefore, the question of whether schizophrenia may be diagnosed during the prodromal phase is of great theoretical and practical interest. Previous studies addressing this question have found that prodromal symptoms have, at best, a modest accuracy for predicting a diagnosis of schizophrenia.^1-2 Therefore, the findings of Klosterkötter et al³ that prodromal symptoms, as gathered with the Bonn Scale for the Assessment of Basic Symptoms (BSABS), "performed well in the early detection of schizophrenia" and that a subset of symptoms has "particularly high prognostic accuracy"³(p158) convey important diagnostic and therapeutical implications.

The impressive design of their study notwithstanding, a major issue may significantly affect the interpretation and generalizability of the results. In examining the diagnostic accuracy of . . . [Full Text of this Article]