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A Commentary on Cost Utility of the Latest Antipsychotic Drugs in Schizophrenia Study (CUtLASS 1) and Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE)

Arch Gen Psychiatry. 2006;63:1069-1072.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Despite schizophrenia's longstanding affliction of humankind,¹ effective treatments for this debilitating disorder only became available in the middle of the 20th century.² Numerous, now landmark, studies^3-5 demonstrated incontrovertibly that chlorpromazine, the prototypic antipsychotic, was more effective than nonpharmacologic treatment (eg, placebo, psychotherapy) in alleviating the acute symptoms of schizophrenia and preventing their recurrence. Although many effective antipsychotics have been introduced in the wake of chlorpromazine, the pace of real progress through drug development and innovation has been arduous and slow.

Any doubts about this unfortunate reality should be eliminated by the results described in Cost Utility of the Latest Antipsychotic Drugs in Schizophrenia Study (CUtLASS 1),^6-7 which are virtually identical to those described previously from Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE).^8-9 These studies found few differences in effectiveness between first-generation antipsychotics (FGAs) and second-generation antipsychotics (SGAs) in nonrefractory patients—a conclusion that runs counter to the impressions of many clinicians . . . [Full Text of this Article]

AUTHOR INFORMATION
Jeffrey A. Lieberman, MD

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First- and Second-Generation Antipsychotics: Learning From CUtLASS and CATIE
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Outcomes, Costs, and Policy Caution: A Commentary on the Cost Utility of the Latest Antipsychotic Drugs in Schizophrenia Study (CUtLASS 1)
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Bibliography PSYCHOPHARMACOLOGY
Focus 2006;4:512.
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