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Lieberman et al¹ reported a significant decrease in whole-brain gray matter in patients diagnosed with a first episode of schizophrenia spectrum disorders treated with haloperidol but not in those treated with olanzapine. Although Lieberman et al took into consideration several possible confounding factors, weight gain induced by neuroleptics was not accounted for. In a previous study, using a sample overlapping with the present one, it was shown that patients treated with olanzapine gained significantly more weight compared with those treated with haloperidol.² In view of some evidence showing that brain ventricles and brain volume could be affected by the overall body weight³ and nutritional status,⁴ controlling for weight gain may be important. This may be relevant since patients treated with haloperidol had, on average, a longer duration of illness, which may be associated with more protracted poor nutritional habits. In fact, if we consider only measurements from weeks 12, 24, . . . [Full Text of this Article]

AUTHOR INFORMATION
Ridha Joober, MD, PhD; Norbert Schmitz, PhD; Ashok Malla, MD; Sarojini Sengupta, PhD; Sherif Karma, MD

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