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Arch Gen Psychiatry. 2006;63:246-248.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Suicide is the third leading cause of death in the United States at ages 10 through 24 years.¹ Major depressive disorder and depressive phases of bipolar I and II disorders are associated with most suicides. Among patients with these disorders, suicide rates are 20-times or more higher than the international general population rate of about 0.015% per year.^2-3 In addition, a lower ratio of attempted-to-completed suicide (approximately 5:1) than in the general population (approximately 25:1) suggests greater lethality of intent or methods of attempts among patients with mood disorder.^{2, 4-5}

The major public health significance of suicide and its strong association with depressive disorders encourage consideration of effects of psychiatric treatments on suicidal risk. Only clozapine has a Food and Drug Administration–approved indication for reducing risk of suicidal behavior in patients with schizophrenia, based on evidence that includes a controlled comparison with olanzapine treatment.^6-8 There is also evidence for major reduction . . . [Full Text of this Article]

AUTHOR INFORMATION
Ross J. Baldessarini, MD; Maurizio Pompili, MD; Leonardo Tondo, MD

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