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5-Lipoxygenase as a Possible Biological Link Between Depressive Symptoms and Atherosclerosis
Hari Manev, MD, PhD;
Radmila Manev, MD
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Stewart and colleagues1 provided compelling evidence for the association between depressive symptoms and the progression of subclinical atherosclerosis. In a 3-year study, they found that higher levels of depressive symptoms (eg, anhedonia, fatigue, and sleep/appetite disturbance) at baseline were associated with a greater 3-year change in carotid intima-media thickness (IMT), and they suggested that depression may play a role in the earlier stages of the development of coronary artery disease. They acknowledged that it is unlikely that the symptoms per se are the pathobiological mechanism of atherosclerosis. A likely explanation for the observed association between depressive symptoms and atherosclerosis is that both are triggered and/or maintained by a common biological mechanism. The Stewart et al study1 included only healthy, older individuals, and the authors suspect that the association they observed may be specific to this population. A putative common mechanism that is affected . . . [Full Text of this Article]
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Arch Gen Psychiatry. 2007;64(2):225-233.
ABSTRACT
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Depression, inflammation, and cardiovascular disease is 5-lipoxygenase the missing link?
Manev et al.
J Am Coll Cardiol 2008;51:1990-1991.
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