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David J. Miklowitz, PhD; Michael W. Otto, PhD; Ellen Frank, PhD; Noreen A. Reilly-Harrington, PhD; Stephen R. Wisniewski, PhD; Jane N. Kogan, PhD; Andrew A. Nierenberg, MD; Joseph R. Calabrese, MD; Lauren B. Marangell, MD; Laszlo Gyulai, MD; Mako Araga, MS; Jodi M. Gonzalez, PhD; Edwin R. Shirley, PhD; Michael E. Thase, MD; Gary S. Sachs, MD

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We appreciate the comments by Drs Saddichha and Kumar. The Canadian treatment guidelines they cited¹ did not conclude that CBT was ineffective for bipolar disorder. In fact, the guidelines cite several single-center studies that found positive evidence for CBT in relapse prevention^2-3 and 1 multicenter trial that observed prophylaxis, although only among patients with fewer than 12 prior episodes.⁴

The patients consenting to the STEP-BD psychotherapy trial were drawn from 2689 patients with bipolar depression treated in study-affiliated STEP-BD clinics. Of these, 236 patients were eligible and willing to accept random . . . [Full Text of this Article]

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