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Stephen Lawrie, MD

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Velakoulis and colleagues¹ are to be congratulated on conducting an impressively large study of medial temporal lobe volumes in patients at different stages of psychosis. They do, however, overinterpret their results. In particular, they say in the "Abstract" that "Medial temporal lobe structural changes are not seen until after the onset of psychotic illness. . . . "^1(p139) This statement and some others in the "Comment" section of the article contradict a much larger body of literature, and even their own previous studies,^2-3 and appear to conflate vulnerability to, prediction of, and progression toward psychosis. Further, there are reasons to believe that despite the size of this current study, Velakoulis et al may be presenting some false-negative results.

The vulnerability analysis in the article is the contrast of medial temporal lobe volumes in the ultra-high-risk (UHR) group and healthy controls, which was not statistically significant. Velakoulis et al acknowledge that their . . . [Full Text of this Article]

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