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Amygdala Volume Status Might Reflect Dominant Mode of Emotional Information Processing
Ludger Tebartz van Elst, MD, PD;
Dieter Ebert, MD;
Bernd Hesslinger, PD, MD
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Recently, Velakoulis et al1 reported very interesting morphometric findings in a large sample of patients with different psychotic disorders. While patients with chronic schizophrenia displayed bilateral hippocampal volume reduction, patients with first-episode schizophrenia had only left hippocampal volume reduction and patients with schizophreniform disorder did not display hippocampal volume reduction at all. In contrast, patients with first-episode nonschizophrenic psychosis displayed amygdala enlargement. Velakoulis et al stress the possibility that increased amygdala volumes might be a nonspecific marker for the presence of a major affective syndrome rather than a diagnostic endophenotype of a specific nosological entity like, for example, major depression or schizophrenia. We want to support this notion and stress that amygdala enlargement has been reported in quite different neuropsychiatric entities ranging from unipolar and bipolar depression2-3 to dysthymia in epilepsy,4 generalized anxiety disorder,5 or psychosis in . . . [Full Text of this Article]
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Amygdala Volume Status Might Reflect Dominant Mode of Emotional Information Processing—Reply
Dennis Velakoulis, Stephen Wood, Michael Wong, Patrick McGorry, Alison Yung, Lisa Phillips, De Smith, Warrick Brewer, Tina Proffitt, Patricia Desmond, and Christos Pantelis
Arch Gen Psychiatry. 2007;64(2):252-253.
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