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Ridha Joober, MD, PhD; Sarojini Sengupta, PhD; Norbert Schmitz, PhD

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Research testing the interaction between measured genes and measured environments in psychiatric disorders was promoted in a recent review by Moffitt et al¹ in the ARCHIVES. In presenting the emerging gene x environment interaction findings, Caspi et al² cite their finding of an interaction between the genetic variants of monoamine oxidase A conferring low enzymatic activity and childhood maltreatment to increase the risk for violent behavior. Moffitt et al cite one replication of this finding by Foley et al³ that was published in the ARCHIVES. A careful perusal of this latter study, which has now been cited 19 times, shows that it is flawed both in its analyses and interpretation. First, Foley et al argued that the results obtained with logistic regression are likely to be more robust than results obtained within a linear regression framework. . . . [Full Text of this Article]

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