This Article  • Full text  • PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Topic Collections  • Psychopharmacology  • Public Health  • Substance Abuse/ Alcoholism  • Statistics and Research Methods  • Drug Therapy  • Drug Therapy, Other  • Alert me on articles by topic  Social Bookmarking   What's this?

Darius A. Rastegar, MD

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Comer and colleagues¹ have shown that an injectable, sustained-release formulation of naltrexone can be effective for the treatment of opioid dependence in selected individuals. While these findings are promising, the impact of this treatment option will likely be limited by low rates of patient acceptance.² Unfortunately, the authors have given us a long list of exclusion criteria but do not provide any data on the number of heroin-dependent men and women who were screened to recruit the 60 subjects in their study. Furthermore, it appears that they used a run-in period during which all subjects received naltrexone to see whether "they were willing and able to tolerate the effects of depot naltrexone"; it would be very helpful if the authors reported how many subjects dropped out during this phase of the trial. I am surprised that the Archives did not adhere to the CONSORT guidelines³ (which . . . [Full Text of this Article]

AUTHOR INFORMATION


CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati     What's this?