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CUtLASS Confirms CATIE
Jim Mintz, PhD;
Alex Kopelowicz, MD
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The Cost Utility of the Latest Antipsychotic Drugs in Schizophrenia Study (CUtLASS)1 of the relative effectiveness of first (FGA)- and second (SGA)-generation antipsychotic treatments of schizophrenia reports negative findings, concluding that "there is no disadvantage across 1 year . . . in using FGAs. . . . "1(p1079) In one commentary,2 Lieberman calls the findings of CUtLASS and the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) study "virtually identical," clearly referring to what he calls the "sobering"2(p1071) conclusion that "these studies found few differences in effectiveness between first-generation antipsychotics (FGAs) and second-generation antipsychotics (SGAs). . . . "2(p1069) In another commentary,3 Rosenheck writes that CUtLASS "echoes" CATIE, which "similarly, found no significant differences in time to all-cause discontinuation, the primary outcome. . . . "2(p1075)
These 2 major studies differed in the measure of drug "effectiveness." CUtLASS used "quality of life," and CATIE used all-cause discontinuation. As it happens, CUtLASS also presents data on all-cause discontinuation in the . . . [Full Text of this Article]
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