This Article  • Full text  • PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Contact me when this article is cited  Related Content  • Related article  • Similar articles in this journal  Topic Collections  • Genetics  • Genetic Disorders  • Depression  • Alert me on articles by topic

Zoltan Rihmer, MD, PhD, DSc; Xenia Gonda; Kareen K. Akiskal; Hagop S. Akiskal, MD

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

In the interesting study by Neumeister et al,¹ they found that behavioral responses to tryptophan depletion (TD) were affected by a polymorphism in the promoter of the serotonin transporter gene (5-HTTLPR) in patients with remitted major depressive disorder and healthy controls. Among the 26 controls, TD induced an increase in Hamilton Depression Rating Scale total scores from baseline to 7 hours after the ingestion of the amino acid mixture in S/S and L/S but not in L/L carriers. Similarly, controls also showed increased anxiety scores in the S/S and L/S subgroups but not in the L/L subgroup.¹

These results become more interesting in light of our recent study² showing a significant association between S/S and S/L carriers of . . . [Full Text of this Article]

AUTHOR INFORMATION

RELATED ARTICLE

Differential Effects of 5-HTTLPR Genotypes on the Behavioral and Neural Responses to Tryptophan Depletion in Patients With Major Depression and Controls
Alexander Neumeister, Xian-Zhang Hu, David A. Luckenbaugh, Markus Schwarz, Allison C. Nugent, Omer Bonne, Peter Herscovitch, David Goldman, Wayne C. Drevets, and Dennis S. Charney
Arch Gen Psychiatry. 2006;63(9):978-986.
ABSTRACT | FULL TEXT