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Gene–Brain Structure Relationships: Arbitrary Assumptions of Heterogeneity Generate Unfalsifiable Claims—Reply
Hugh M. D. Gurling, MD, MPhil, FRCPsych;
Hugo Critchley, MB, ChB, DPhil, MRCPsych;
Susmita R. Datta, BSc;
Andrew McQuillin, PhD;
Ekaterina Blaveri, PhD;
Srinivasa Thirumalai, MD, MRCPsych;
Jonathan Pimm, MPhil, MBBS, MRCPsych;
Robert Krasucki, BSc, MBBS, MRCPsych;
Gursharan Kalsi, PhD;
Digby Quested, MD, MRCPsych;
Jacob Lawrence, MBBS, BSc, MRCPsych;
Nicholas Bass, MB, ChB, BSc, MRCPsych;
Khalid Choudhury, BSc;
Vinay Puri, BSc;
Owen O’Daly, BSc;
David Curtis, MBBS, MD, PhD, MRCPsych;
Douglas Blackwood, PhD, MRCPsych;
Walter Muir, PhD, MRCPsych;
Anil K. Malhotra, MD;
Robert W. Buchanan, MD;
Catriona D. Good, MB, ChB, FFRad, FRCR;
Richard S. J. Frackowiak, MD, DSc, FRCP, FMedSci;
Raymond J. Dolan, MD, FRCPsych, FMedSci
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In reply
We do not agree with the criticisms that Crow and DeLisi make of our research. The claim that we have been arbitrarily assuming locus heterogeneity in schizophrenia on a post hoc basis is at odds with what has already been published . . . [Full Text of this Article]
AUTHOR INFORMATION
RELATED LETTER
Gene–Brain Structure Relationships: Arbitrary Assumptions of Heterogeneity Generate Unfalsifiable Claims
Tim J. Crow and Lynn DeLisi
Arch Gen Psychiatry. 2007;64(9):1097-1098.
EXTRACT
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Genetic Association and Brain Morphology Studies and the Chromosome 8p22 Pericentriolar Material 1 (PCM1) Gene in Susceptibility to Schizophrenia
Hugh M. D. Gurling, Hugo Critchley, Susmita R. Datta, Andrew McQuillin, Ekaterina Blaveri, Srinivasa Thirumalai, Jonathan Pimm, Robert Krasucki, Gursharan Kalsi, Digby Quested, Jacob Lawrence, Nicholas Bass, Khalid Choudhury, Vinay Puri, Owen O’Daly, David Curtis, Douglas Blackwood, Walter Muir, Anil K. Malhotra, Robert W. Buchanan, Catriona D. Good, Richard S. J. Frackowiak, and Raymond J. Dolan
Arch Gen Psychiatry. 2006;63(8):844-854.
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