This Article  • Full text  • PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Contact me when this article is cited  Related Content  • Related article  • Related letter  • Similar articles in this journal  Topic Collections  • Neurology  • Nutritional and Metabolic Disorders  • Metabolism  • Depression  • Psychopharmacology  • Drug Therapy  • Drug Therapy, Other  • Alert me on articles by topic  Social Bookmarking   What's this?

David A. Barton, FRANZP; Murray D. Esler, MBBS, PhD; Gavin W. Lambert, PhD

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

In reply

Dr Papadopoulos raises some interesting and pertinent points. In our study, we did not take into account an individual's history of exposure to sunlight.¹ Whether our depressed cohort was less exposed to sunlight compared with healthy subjects because of limited outdoor activities remains problematic. If so, this might be expected to lower their brain serotonin turnover.²

In the majority of patients (n = 6), the initial investigation was performed in spring with follow-up in summer; in 3 patients, the pattern was autumn/winter; and in the remaining patient, initial testing was in winter with the posttreatment investigation in spring. Sunlight duration pretreatment and posttreatment was not identical (mean [SD], 5.9 [3.5] hours/day vs 7.7 [3.7] hours/day; P = .26). Given this pattern of testing, and that we,² and others,^3-5 have previously demonstrated a positive interaction between brain serotonin, season, . . . [Full Text of this Article]

AUTHOR INFORMATION


CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati     What's this?

RELATED ARTICLE

Elevated Brain Serotonin Turnover in Patients With Depression: Effect of Genotype and Therapy
David A. Barton, Murray D. Esler, Tye Dawood, Elisabeth A. Lambert, Deepak Haikerwal, Celia Brenchley, Florentia Socratous, Jacqueline Hastings, Ling Guo, Glen Wiesner, David M. Kaye, Richard Bayles, Markus P. Schlaich, and Gavin W. Lambert
Arch Gen Psychiatry. 2008;65(1):38-46.
ABSTRACT | FULL TEXT  

RELATED LETTER

Season as a Possible Confounding Factor in Reduced Brain Serotonin Turnover Following Selective Serotonin Reuptake Inhibitor Therapy
Fotios C. Papadopoulos
Arch Gen Psychiatry. 2008;65(10):1224-1225.
EXTRACT | FULL TEXT