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No Evidence of Decrease in Cognitive Function in Users of Low-Dose Ecstasy
Teri S. Krebs, BSc;
Pål-Ørjan Johansen
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Unlike nearly all previous research on the issue of potential long-term effects of Ecstasy use, the Netherlands XTC Toxicity team used a prospective study design, assessing people before and after they decided to take Ecstasy. It is precisely because Schilt and colleagues1 are engaged in conducting one of the most ambitious and carefully thought out programs of research that seeks to overcome the problems of retrospective study designs that we remark on the serious problems with this report. Schilt and colleagues overstate the findings of their nonrandomized study when they conclude that their data show that "even a first low cumulative dose of Ecstasy is associated with decline in verbal memory."1(p728) All 12 cognitive test scores in both groups were within the normal range, and no decreases were demonstrated in the Ecstasy group over time.
Schilt and colleagues describe an increase in verbal memory . . . [Full Text of this Article]
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RELATED LETTER
No Evidence of Decrease in Cognitive Function in Users of Low-Dose Ecstasy—Reply
Thelma Schilt, Maartje M. de Win, Maarten Koeter, Gerry Jager, Dirk J. Korf, Wim van den Brink, and Ben Schmand
Arch Gen Psychiatry. 2008;65(2):236-237.
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RELATED ARTICLE
Cognition in Novice Ecstasy Users With Minimal Exposure to Other Drugs: A Prospective Cohort Study
Thelma Schilt, Maartje M. L. de Win, Maarten Koeter, Gerry Jager, Dirk J. Korf, Wim van den Brink, and Ben Schmand
Arch Gen Psychiatry. 2007;64(6):728-736.
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