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Preben Bo Mortensen, MD, DMSc; William W. Eaton, PhD

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

We have with great interest read the recent report from Finland by Juvonen et al¹ of a reduced incidence of schizophrenia in patients with type 1 diabetes mellitus. Their finding replicates and strengthens our marginally significant finding of a negative association (males, odds ratio [OR], 0.7; 95% confidence limits, 0.5, 1.1; females, OR, 0.7; 95% confidence limits, 0.4, 1.0) in our report from 2006 based on independent registers in Denmark.²

Juvonen et al suggest linkage disequilibrium of protective and liability genes for the 2 diseases as one explanation for the negative association. However, in our study, a parental history of type 1 diabetes was associated with an increased risk of schizophrenia in the offspring (OR, 1.5; 95% confidence limits, 1.3, 1.7). Therefore, linkage disequilibrium alone is unlikely to explain the negative association. If linkage disequilibrium is the explanation, one must hypothesize . . . [Full Text of this Article]

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Incidence of Schizophrenia in a Nationwide Cohort of Patients With Type 1 Diabetes Mellitus
Hannu Juvonen, Antti Reunanen, Jari Haukka, Maria Muhonen, Jaana Suvisaari, Ritva Arajärvi, Timo Partonen, and Jouko Lönnqvist
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