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"Familiality" or Heritability
Kenneth S. Kendler, MD;
Michael C. Neale, PhD
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In their recent article, Hong et al1 reported heritabilities of auditory sensory gating. As they defined it in their article, heritability reflects the proportion of overall variability in a trait in a population that results from additive genetic effects. Within human populations, such estimates have traditionally relied on special relationships that can (with some well-understood limitations) disentangle genetic from familial-environmental effects. The most popular of these methods have been twin studies comparing monozygotic and dizygotic twin pairs and various adoption designs.
However, in their study, Hong et al do not use these standard approaches. Rather, they examine individuals with schizophrenia (n = 102) and 74 of their first-degree relatives. Heritabilities are estimated from sibling-sibling and parent-offspring pairs using the program SOLAR.2 The problem with this approach is that data from these 2 relationships alone do not contain information that can, with any confidence, disentangle . . . [Full Text of this Article]
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Sensory Gating Endophenotype Based on Its Neural Oscillatory Pattern and Heritability Estimate
L. Elliot Hong, Ann Summerfelt, Braxton D. Mitchell, Robert P. McMahon, Ikwunga Wonodi, Robert W. Buchanan, and Gunvant K. Thaker
Arch Gen Psychiatry. 2008;65(9):1008-1016.
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