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Results From the National Epidemiologic Survey on Alcohol and Related Conditions

Bridget F. Grant, PhD, PhD; Frederick S. Stinson, PhD; Deborah A. Dawson, PhD; S. Patricia Chou, PhD; Mary C. Dufour, MD, MPH; Wilson Compton, MD; Roger P. Pickering, MS; Kenneth Kaplan, BS

Arch Gen Psychiatry. 2004;61:807-816.

Background  Uncertainties exist about the prevalence and comorbidity of substance use disorders and independent mood and anxiety disorders.

Objective  To present nationally representative data on the prevalence and comorbidity of DSM-IV alcohol and drug use disorders and independent mood and anxiety disorders (including only those that are not substance induced and that are not due to a general medical condition).

Design  Face-to-face survey.

Setting  The United States.

Participants  Household and group quarters' residents.

Main Outcome Measures  Prevalence and associations of substance use disorders and independent mood and anxiety disorders.

Results  The prevalences of 12-month DSM-IV independent mood and anxiety disorders in the US population were 9.21% (95% confidence interval [CI], 8.78%-9.64%) and 11.08% (95% CI, 10.43%-11.73%), respectively. The rate of substance use disorders was 9.35% (95% CI, 8.86%-9.84%). Only a few individuals with mood or anxiety disorders were classified as having only substance-induced disorders. Associations between most substance use disorders and independent mood and anxiety disorders were positive and significant (P<.05).

Conclusions  Substance use disorders and mood and anxiety disorders that develop independently of intoxication and withdrawal are among the most prevalent psychiatric disorders in the United States. Associations between most substance use disorders and independent mood and anxiety disorders were overwhelmingly positive and significant, suggesting that treatment for a comorbid mood or anxiety disorder should not be withheld from individuals with substance use disorders.

From the Laboratory of Epidemiology and Biometry, Division of Intramural Clinical and Biological Research (Drs Grant, Stinson, Dawson, and Chou and Mr Pickering), and the Office of the Director (Dr Dufour), the National Institute on Alcohol Abuse and Alcoholism, and the Division of Epidemiology, Services, and Prevention Research, National Institute on Drug Abuse (Dr Compton), National Institutes of Health, Department of Health and Human Services, Bethesda, Md; and the Demographic Surveys' Division, US Census Bureau, Suitland, Md (Mr Kaplan).

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