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A Comparison of Normal and Schizophrenic Subjects

GERALD COHEN, Ph.D.; BERNARD HOLLAND, M.D.; MARCEL GOLDENBERG, M.D.

AMA Arch Gen Psychiatry 1959;1(2):228-231.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Introduction

Recently, in the course of experiments dealing with intravenous infusions of epinephrine and norepinephrine in man,¹ occasion presented itself to perform infusions on a group of normal subjects and on a group of schizophrenic patients. It appeared that data concerning plasma concentrations of epinephrine and norepinephrine during infusions had bearing on recent suggestions that schizophrenia might be related to a faulty metabolism of either of these two substances. Hoffer and co-workers,^2,3 for instance, had presented evidence suggestive that certain oxidized derivatives of epinephrine, namely, adrenochrome (3-hydroxy-2,3dihydro-1-methylindole-5,6-quinone) and adrenolutin (3,5,6-trihydroxy-1-methylindole) were capable of producing transient psychoses and other mental aberrations in man when administered intravenously or orally. Thus, the view was advanced³ that a defect in epinephrine metabolism resulting in the formation of excessive quantities of adrenochrome or adrenolutin might be an etiologic factor in schizophrenia. In support of this . . . [Full Text PDF of this Article]

Author Affiliations
New York With the Technical Assistance of Joanne Sha

From the Departments of Biochemistry, Medicine, and Psychiatry of Columbia University College of Physicians and Surgeons; and from the New York State Psychiatric Institute, and the Presbyterian Hospital.

Present address (Dr. Holland): Department of Psychiatry, Emory University School of Medicine, Atlanta, Ga.

Footnotes
Submitted for publication Sept. 29, 1958.

Presented before the Intersociety Session of the 42d Annual Meeting of the Federation of American Societies for Experimental Biology, Philadelphia, April 14-18, 1958.

Supported by Research Grant H-1045 (C-6) of the U. S. Public Health Service, National Institutes of Health; and by the Florence L. Pond Gift to the Presbyterian Hospital.

Dr. Goldenberg died on July 30, 1958.

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