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Lipid Factors in the Production of Enephalomalacia in the Chick
B. CENTURY, Ph.D.;
M. K. HORWITT, Ph.D.;
P. BAILEY, M.D.
AMA Arch Gen Psychiatry 1959;1(4):420-424.
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Studies of chick encephalomalacia, or "crazy-chick" disease, may provide basic information about brain metabolism. The techniques and some of the variables involved are described in this paper. The requirement for tocopherol, which by itself seems to be a specific preventative of encephalomalacia, is not absolute for any given species, but may depend on the presence of various types of biological and dietary stresses, especially those related to lipids in the diet.1 Effects of ingested lipids on tocopherol requirement can be studied in chicks by taking the appearance of symptoms and lesions of encephalomalacia as the end-point in the demonstration of deficiency. The most effective diets used by other investigators to produce encephalomalacia contained large amounts of protein and highly unsaturated fish oils, hog liver fatty acids, or lard.2-6 It has been suggested that the intake of unsaturated oxidizable lipids is of primary
. . . [Full Text PDF of this Article]
Author Affiliations
Elgin, Ill.; Chicago
From the Biochemical Research Laboratory, Elgin State Hospital, and the Department of Neurology and Neurological Surgery, University of Illinois College of Medicine.
Footnotes
Submitted for publication Feb. 9, 1959.
Supported by grants-in-aid from the Illinois Mental Health Fund, National Institutes of Health (A-1126[C1]), and National Vitamin Foundation.
We are indebted to Distillation Products, Inc., for stripping most of the tocopherol from the corn oil and lard used in this study.
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