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A. Reproducibility and Effect of Drugs B. Sedation Threshold in Neurotic and Psychotic Depression

NYMGAARD KIRSTEN, M.D.

AMA Arch Gen Psychiatry 1959;1(5):530-536.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Introduction

The concept of the sedation threshold was introduced by Shagass^3-9 in 1955, and it has since received considerable attention. The sedation threshold is defined by Shagass as the amount of amobarbital sodium, expressed in milligrams per kilogram of body weight, required to produce an inflection point in the amplitude curve which appears when the frontal 15- to 30-cps electroencephalographic activity is plotted against the amount of amobarbital sodium given. Nearly all such curves contain an inflection point at which the curve, after a steep rise, tends to plateau or fall. The appearance of this inflection point is often coincident with onset of slurred speech, and the latter sign has, therefore, been used as an indication that a sufficient amount of amobarbital has been given.

Shagass found that the sedation threshold was a relatively constant biological characteristic of the normal subject, as indicated by . . . [Full Text PDF of this Article]

Author Affiliations
Risskov, Denmark

From Aarhus University, Department of Psychiatry, Psychiatric Hospital.

Footnotes
Submitted for publication March 20, 1959.

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