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Simulation of Schizophrenic Performance with Sernyl, LSD-25, and Amobarbital (Amytal) Sodium; I. Attention, Motor Function, and Proprioception

GERALD ROSENBAUM, Ph.D.; BERTRAM D. COHEN, Ph.D.; ELLIOT D. LUBY, M.D.; JACQUES S. GOTTLIEB, M.D.; DONALD YELEN, B.A.

AMA Arch Gen Psychiatry 1959;1(6):651-656.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Study of the pathological mechanisms implicated in schizophrenia has recently been accelerated by the production of model psychoses through the use of Psychotomimetic drugs. Our laboratories have previously reported⁶ Psychotomimetic effects with Sernyl, l-(l-phenylcyclohexyl) piperidine monohydrochloride. This drug is one of a class of new chemical compounds which function as sensory blocking agents, with anesthetic and sedative properties. It was found to produce severe disturbances in body image, affect, attention, and thinking which closely approximated the primary symptoms of schizophrenia. Depersonalization, feelings of isolation and estrangement, concreteness, hypnagogic states, and repetitive motor behavior occurred in patients following intravenous infusion of this drug.

The present studies were conducted in an attempt to isolate the mechanism responsible for the effects of Sernyl and its relevance to the psychopathology of schizophrenia. A number of psychological functions characteristically associated with the primary pathology of schizophrenia were system . . . [Full Text PDF of this Article]

Author Affiliations
Detroit

From the Lafayette Clinic and Wayne State University College of Medicine.

Footnotes
Submitted for publication May 5, 1959.

The authors wish to express their gratitude to Parke, Davis & Company for supplying the Sernyl used in this study and subsidizing the normal controls.

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