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JAMES L. GIBBONS, MB, MRCP, DPM

Arch Gen Psychiatry. 1964;10(6):572-575.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Introduction

In a previous study¹ elevated plasma cortisol levels were found in patients suffering from depressive illness, a finding which confirmed the original observations of Board et al.^2,3 In a group of 18 cases, in which plasma cortisol was measured at weekly intervals, there was a positive correlation between the height of the plasma level and the severity of the depression. It was concluded that increased adrenocortical activity, already well-known as a feature of anxiety,⁴ was also a feature of depression. Since this conclusion was based on a study of only one index of adrenocortical function, further evidence was sought by measuring the secretion rate of cortisol in a second group of depressed patients.

Case Material and Methods

The investigation was conducted on 15 patients admitted to the metabolic unit of the Maudsley Hospital with a diagnosis of depression. There were five . . . [Full Text PDF of this Article]

Author Affiliations

From the Institute of Psychiatry, Maudsley Hospital, London, SE5.

Footnotes

The work was supported by grants from the Ford Foundation and from the research fund of the Bethlem Royal and Maudsley Hospitals.

Beef liver β-glucuronidase buffered in acetate to pH 5 and used for determination of steroids in urine and blood.

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