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In the Cerebrospinal Fluid in Schizophrenia

JACK PETER GREEN, PhD, MD; ROGER P. ATWOOD, MD; DANIEL X. FREEDMAN, MD

Arch Gen Psychiatry. 1965;12(1):90-95.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Derivatives of neuraminic acid^1,2 (or sialic acids) are widely distributed in tissues. In brain, neuraminic acid is found in especially high concentration in gray matter,^3,4 the pineal body,⁵ and the hypophysis.⁶ As a component of gangliosides, N-acetylneuraminic acid accumulates in the brains of patients with infantile amaurotic familial idiocy.^7,8 The function of neuraminic acid is not known, but it has been implicated in the binding of biogenic amines,^9,10 and in brain its concentration appears to fall after treatment with reserpine and chlorpromazine.⁴⁴ Blood levels of neuraminic acid are altered in many diseases.¹¹ In the cerebrospinal fluid (CSF), changes have been noted in parkinsonism¹² and in schizophrenia.

Bogoch¹³ first reported that CSF of schizophrenic patients contains abnormally low levels of neuraminic acid. This conclusion was based on values obtained by measuring the chromophore . . . [Full Text PDF of this Article]

Author Affiliations
NEW HAVEN, CONN

From the Departments of Pharmacology and Psychiatry, Yale University School of Medicine. Some of the results were taken from a thesis submitted by Dr. Atwood in partial fulfillment of the requirements for the degree of Doctor of Medicine from Yale University.

Footnotes
Submitted for publication June 3, 1964.

This work was supported by grants from the National Institute of General Medical Sciences, Public Health Service (GM-10313-02) and the American Heart Association (60-G-71). Dr. Green and Dr. Freedman are recipients of Career Development Awards of the National Institute of General Medical Sciences (2K3-GM-2459) and the National Institute of Mental Health (K-MH18566), respectively.

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