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Review of the Literature and Report of Seven Cases

AARON PLACHTA, MD

Arch Gen Psychiatry. 1965;12(2):152-158.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

IT WOULD BE superfluous to introduce additional examples of the documental rise in attempted and completed suicides^28,52,54,68 and sudden unexplained deaths^{10,12,26,67,71} among the normal and schizophrenic population therapeutically exposed to tranquilization. The purpose of this paper is to introduce the mechanism and pathogenesis previously not documented, as far as I can ascertain, in case reports of sudden unexplained deaths of patients on tranquilization.

Asphyxia, a term applied to a definite sequence of clinical symptoms, is a result of a physiopathological process implicated and influenced by ataraxics acting upon the central nervous system (CNS)^3,4,16,37 resulting in gastroesophageal reflux,^7,8,14,22,31 respiratory insufficiency and failure.^23,34,46

The adverse behavioral affect on the CNS attributed to chlorpromazine,^6,18,20,35 promazine,^44,47,73 reserpine,^15,74 and other tranquilizers^17,19,63,64 emerged with a characteristic clinical pattern in both children and adults, ex . . . [Full Text PDF of this Article]

Author Affiliations
MONTROSE, NY

From the Department of Pathology and Clinical Pathology, Franklin Delano Roosevelt Veterans Administration Hospital. Chief, Laboratory Service. Reprint requests to Montrose, NY 10548.

Footnotes
Submitted for publication Sept 16, 1964.

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