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A Review

PETER ROGER BREGGIN, MD

Arch Gen Psychiatry. 1965;12(3):255-259.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

WHEN HEN FELDBERG and Sherwood demonstrated that intraventricular injections of epinephrine (Adrenaline) in dogs caused "sedative-like" behavioral depression, they suggested that epinephrine secretion during anxiety in humans might cause analogous symptoms of fatigue and somnolence.¹⁸ Little or no attention was subsequently given this hypothesis; Feldberg himself did not mention it in his recent (1963) book about the pharmacology of the brain.¹⁷ The hypothesis has received little attention for two reasons: first, there has been little evidence that systemic epinephrine could reach the brain, and second, there has been little or no evidence that systemically administered epinephrine could produce sedative-like or fatiguelike effects.

Both these objections have been modified by recent experimental findings. First, radioactively tagged epinephrine has been shown to cross the blood-brain barrier in the region of the hypothalamus during sustained systemic infusions,^1,45 and second, epinephrine . . . [Full Text PDF of this Article]

Author Affiliations
SYRACUSE, NY

State University of New York, Upstate Medical Center. Resident and Assistant Instructor, Department of Psychiatry, 1964; Massachusetts Mental Health Center, Resident in Psychiatry; and Harvard Medical School, Teaching Fellow in Psychiatry, 1963-1964.

Footnotes
Submitted for publication Sept 25, 1964.

Reprint requests to 342 Roosevelt Ave, Syracuse, NY 13210.

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