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Patients Treated With Monoamine Oxidase Inhibitors

LEE C. PARK, MD; ROSS J. BALDESSARINI, MD; SEYMOUR S. KETY, MD

Arch Gen Psychiatry. 1965;12(4):346-351.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Introduction

IN 1952, Osmond and Smythies and Harley-Mason suggested the possibility of a disturbance in transmethylation in schizophrenia.²⁰ Subsequently, Hoffer and his associates administered niacin and niacinamide to chronic schizophrenic patients in the hope that these methyl acceptors would competitively inhibit other methylations. The clinical improvements which they saw¹⁴ have not been confirmed.

Pollin et al²² administered large doses of 1methionine and ordinary doses of iproniazid to chronic schizophrenic patients to learn whether possible increases in amounts of methylated amines would potentiate a schizophrenic process. The monoamine oxidase inhibitor (MAOI) was expected to slow amine catabolism, and it was felt that the methionine load might favor the formation of methylated compounds¹⁵ by way of S-adenosylmethionine, shown by Cantoni⁶ to play a crucial role in biological transmethylations. They reported that 4 of their 12 patients demonstrated a . . . [Full Text PDF of this Article]

Author Affiliations
BALTIMORE; BETHESDA, MD

From the Johns Hopkins University, Assistant Professor of Psychiatry (Dr. Park); and from the Laboratory of Clinical Science, National Institute of Mental Health (Dr. Baldessarini); and National Institute of Mental Health, National Institutes of Health, US Department of Health, Education, and Welfare, Chief, Laboratory of Clinical Science. (Dr. Kety).

Rubel, Durell, and Kety, unpublished observations.

Dr. Albert A. Kurland, Director of Research, Department of Mental Hygiene, Maryland, cooperated in this study. Mr. Kenneth McCusker and Mrs. Kester Johnson of the Spring Grove Research Staff gave assistance.

Hoffman-LaRoche, Inc., supplied the medications.

Footnotes
Submitted for publication Oct 23, 1964.

Reprint requests to Johns Hopkins University, Baltimore, Md 21205 (Dr. Park).

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