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I. Glucose and Plasma Free Fatty Acid

G. RICHARD van SICKLE, MD; ROBERT H. McCluer, PhD; CHARLES R. KISTLER, MD; NORMA F. Besch, PhD

Arch Gen Psychiatry. 1966;14(3):284-286.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

P. S. MUELLER, in 1961, examined the plasma free fatty acid (FFA) response of chronic schizophrenics to I.M. insulin. In a preliminary study of 12 patients and seven normal controls,¹ Mueller found differences in the responsivity of the two groups. The normals had a significant fall in plasma FFA but the schizophrenics did not. In fact, it was noted that three of the patients had apparent paradoxical responses to insulin in that there was no change or a rise in FFA levels.

A repetition of the study¹ with an increased number of controls confirmed the findings of the first experiment so that Mueller decided to modify the experimental design² using the standard intravenous insulin tolerance test. Ten patients and ten controls were studied; plasma FFA was measured at 0, 15, 30, and 45 minutes. This time however, the schizophrenics differed from normals only at 45 minutes. . . . [Full Text PDF of this Article]

Author Affiliations
COLUMBUS, OHIO

From the Department of Psychiatry, Ohio State University Medical School, Columbus, Ohio. Division of General Psychiatry (Dr. van Sickle); Division of Behavioral Sciences (Drs. McCluer and Besch); and Resident physician (Dr. Kistler). Dr. Kistler is now at US Naval Hospital, Neuropsychiatric Service, Camp Pendleton, Calif.

Footnotes
Submitted for publication July 23, 1965.

Reprint requests to 410 W Tenth Ave, Columbus, Ohio 43210 (Dr. Besch).

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