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II. ACTH and Cortisol*

CHARLES R. KISTLER, MD; NORMA F. BESCH, PhD; G. RICHARD van SICKLE, MD; ROBERT H. McCLUER, PhD; HERMAN MORRIS, MA; DANIEL B. JACKSON, BA

Arch Gen Psychiatry. 1966;14(3):287-290.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

IN VIEW of the central role which stress is assumed to take in many psychophysiologic interpretations of psychiatric disorder, interest has long been focused on the function of the pituitary-adrenal system in psychiatric illness. However, no direct measure of ACTH (adrenocorticotrophic hormone) activity have been obtained in studies of the response of psychotic or nonpsychotic psychiatric patients to stress. In addition, in only a few studies^1-4 have detectable levels of ACTH been reliably established in normal humans with no known endocrine pathology. Thus the report by Vernikos-Danellis and Marks,⁵ in which increased blood levels of ACTH were found 2 minutes after the intravenous administration of epinephrine to normal subjects, was viewed with great interest. Epinephrine was therefore chosen in this study as an adequate stressor with which to compare psychotic patients with nonpsychotic controls. Insulin was chosen for two reasons, one . . . [Full Text PDF of this Article]

Author Affiliations
COLUMBUS, OHIO

From the Department of Psychiatry, Ohio State University Medical School, Columbus, Ohio. Resident physician (Dr. Kistler), now at US Naval Hospital, Neuropsychiatric Service, Camp Pendleton, Calif. Division of Behavioral Sciences (Drs. Besch and McCluer and Mr. Morris and Mr. Jackson); and Division of General Psychiatry (Dr. van Sickle).

Footnotes
Submitted for publication July 23, 1965.

Reprint requests to 410 W Tenth Ave, Columbus, Ohio 43210 (Dr. Besch).

Part I appears in the Archives of General Psychiatry, this issue p 284.

The trivial name, cortisol, is used to refer to pregn-4ene-11β, 17a, 21-triol-3, 20-dione.

The trivial name, corticosterone, is used to refer to pregn-4-ene-11β, 21-diol-3, 20-dione.

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