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Practical Drug Evaluation MethodII. A Drug-Drug Comparison
JOHN D. AINSLIE, MD;
JOHN R. STIEFEL, MD;
MARSHALL B. JONES, PhD
Arch Gen Psychiatry. 1966;15(4):368-372.
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| Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings. |
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THE EVALUATION of psychopharmacologic agents in an outpatient setting presents special problems. Crossover designs are rarely possible, partly because they take too long and partly because psychiatric status changes too rapidly. Drug-placebo and drugdrug designs are the rule. These designs, however, are most vulnerable to withingroup variability, and psychiatric outpatients tend to be very heterogeneous. There is, therefore, a major need for experimental designs and procedures which minimize withingroup variability.
In a recent paper1 the authors described a method of drug evaluation which was intended to meet these difficulties. The method depended on three critical features:
A. In the first two weeks under treatment, psychiatric outpatients typically undergo a marked improvement in Symptomatology.2-5 Associated with this improvement are large amounts of variability. Some patients improve dramatically while others do not improve at all. In the Florida method all patients are
. . . [Full Text PDF of this Article]
Author Affiliations
GAINESVILLE, FLA
From the Department of Psychiatry, College of Medicine, University of Florida; Psychiatric Outpatient Service (Dr. Ainslie); Psychiatric Outpatient Clinic (Dr. Stiefel); departments of psychiatry and psychology (Dr. Jones).
Footnotes
Submitted for publication Feb 2, 1966.
Reprint requests to J. Hillis Miller Health Center, Gainesville, Fla 32603 (Dr. Jones).
Part I, "A Practical Drug Evaluation Method: Imipramine in Depressed Outpatients" may be found in the April 1965 issue of the ARCHIVES, pp 368-373.
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