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I. Distribution in Schizophrenics and Nonschizophrenics

W. W. J. TURNER, MD; H. ISAAC CHIPPS, MS

Arch Gen Psychiatry. 1966;15(4):373-377.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

DESPITE increasingly intensive research over a period of 70 years for a "biochemical lesion" in schizophrenias, none of the many reported has been found to be both reproducible and relevant.^1,2 The very recent demonstration of the presence of 3,4-dimethylphenylethylamine in urine³ may prove to be the first exception; the present report is submitted concerning a potential second.

In 1947 Sjovall⁴ reported that mice who died after intravenous injection of serum of schizophrenics had hemoglobinuria. This hemoglobinuria could be prevented by heating serum to 56 C for 30 minutes without, however, destroying toxicity. Other authors, earlier, had reported a decrease in toxicity upon heating serum.^5,6 No one seems to have connected these observations to the long-studied phenomenon of heterophil antibodies,^7,8 although lethal action of heterologous serum injected into veins of another species had been supposed to be due to antibody-antigen . . . [Full Text PDF of this Article]

Author Affiliations
CENTRAL ISLIP, NY

From the Research Division, Central Islip (New York) State Hospital.

Footnotes
Accepted for publication Jan 4, 1966.

Reprint requests to State of New York, Department of Mental Hygiene, Central Islip State Hospital, Central Islip, New York (Dr. Turner).

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