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I. Demonstration of Antibrain Globulins by Fluorescent Antibody Techniques

ROBERT G. HEATH, MD, DMSc; IRIS M. KRUPP, PhD

Arch Gen Psychiatry. 1967;16(1):1-9.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

PUBLICATIONS from the Tulane laboratories have previously described a unique protein fraction isolated from the serum of schizophrenic patients, which we called taraxein.^1-3 When introduced intravenously into Macaca rhesus monkeys, this fraction caused electroencephalographic abnormalities in focal subcortical regions of the brain that resembled those of psychotic schizophrenic patients. Intravenous use of the fraction in human volunteer-subjects induced symptoms of the psychotic schizophrenic state. Research in other laboratories directed toward isolation and characterization of serum protein fractions of schizophrenic patients has stimulated speculation about the mode of action of taraxein in relation to schizophrenia.^4-10

The possibility of an immunologic mechanism in various disorders of the central nervous system has been investigated. Indirect effects of cancer on the nervous system,¹¹ mechanisms of induction of experimental allergic encephalomyelitis,¹² immunologic mechanisms of certain types of neuromyelitis, and immunologic phenomena in myasthenia gravis . . . [Full Text PDF of this Article]

Author Affiliations
NEW ORLEANS

From the Department of Psychiatry and Neurology, Tulane University School of Medicine, New Orleans.

Footnotes
Submitted for publication May 2, 1966.

Reprint requests to 1430 Tulane Ave, New Orleans, La 70112 (Dr. Heath).

Brain tissues obtained for study were the following. Septal Region.—Rostral border is the rostral extent of the anterior horn of the lateral ventricle; caudal border is the anterior commissure; dorsal border is the roof of the anterior horn of the lateral ventricle; ventral border is the base of the brain; lateral extent is the deepest, or most ventral, extent of the ventricle, which is an arbitrary dividing line between the medial-lying septal region and, on the lateral side, the head of the caudate nucleus.

Caudate Nucleus.—The caudate nucleus is readily visible as a mass on the lateral wall of the ventricle.

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