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II. A Longitudinal Psychoendocrine Study

Edward J. Sachar, MD

Arch Gen Psychiatry. 1967;17(5):554-567.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THIS PAPER will report a longitudinal psychoendocrine study of three parameters of adrenal cortical function in 20 patients hospitalized for depressive illness. The focus of the research was on the question, is adrenal cortical activity characteristically affected in depressive illness? The preceding paper, reviewing the literature on this subject, concluded that most of the reported data was difficult to interpret because of failure to control for significant factors, such as response to admission to the hospital milieu, interfering medications, and selection of appropriate control comparison data. The present study was designed to reexamine the problem of adrenal cortical function in depressed patients under more rigorously controlled conditions.

Methods of Procedure

The basic design was to assess the psychiatric state and measure urinary corticosteroids for three 72-hour periods during depressive illness and for two 72-hour periods following recovery in 20 depressed patients hospitalized on . . . [Full Text PDF of this Article]

Author Affiliations
New York

From the Psychoendocrine Research Laboratory and the Center for Clinical and Metabolic Studies of Affective Disorders, Massachusetts Mental Health Center, and the Department of Psychiatry, Harvard Medical School, Boston. Dr. Sachar is now at Montefiore Hospital and Medical Center, Bronx, NY, and at Albert Einstein College of Medicine, Bronx, NY.

Footnotes
Submitted for publication May 2, 1967.

Read in part at the 122nd annual meeting of the American Psychiatric Association, Atlantic City, NJ, May, 1966.

Reprint requests to Montefiore Hospital and Medical Center, 111 E 210th St, Bronx, NY 10467.

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