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J. MENDELSON, M.D.; P. KUBZANSKY, M.D.; P. H. LEIDERMAN, M.D.; D. WEXLER, M.D.; C. DuTOIT, M.D.; P. SOLOMON, M.D.

AMA Arch Gen Psychiatry 1960;2(2):147-155.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Introduction

A number of recent investigations have demonstrated that sensory deprivation can induce transient but severe cognitive, emotional, and behavioral changes in man.^1,2 Sensory deprivation has been utilized as a technique for producing stress of a nonspecific type, capable of eliciting specific behavioral and physiological responses under controlled conditions.

The advent of recent bioassay and biochemical techniques has permitted the separation and analysis of the adrenal medullary hormones, epinephrine and norepinephrine, in man. Work by von Euler⁴ established that epinephrine normally is secreted only by the adrenal medulla, while norepinephrine is secreted primarily by the endings of peripheral sympathetic nerves and secondarily by the adrenal medulla. Since the early work of Cannon^5,6 and his associates, it has been known that a variety of stress situations may produce an adrenal medullary hormonal response, as reflected in alterations of cardiovascular function. . . . [Full Text PDF of this Article]

Author Affiliations
Boston

From the Psychiatric Laboratory, Boston City Hospital, and the Chemistry Laboratory, Massachusetts General Hospital, Psychiatry Department, Harvard Medical School.

Assistant in Psychiatry, Harvard Medical School; Clinical and Research Fellow in Psychiatry, Massachusetts General Hospital (Dr. Mendelson). Research Associate in Psychology, Department of Psychiatry, Harvard Medical School; Chief Psychologist, Boston City Hospital (Dr. Kubzansky). Instructor in Psychiatry, Harvard Medical School; Research Associate in Psychiatry, Boston City Hospital (Dr. Leiderman). Assistant in Psychiatry, Harvard Medical School; Assisting Physician in Psychiatry, Boston City Hospital (Dr. Wexler). Formerly Director, Chemistry Laboratory, Massachusetts General Hospital; Associate in Medicine, Harvard Medical School (Dr. DuToit). Assistant Clinical Professor of Psychiatry, Harvard Medical School; Physician-in-Chief for Psychiatry, Boston City Hospital (Dr. Solomon).

Dr. DuToit died March 25, 1959.

Footnotes
Submitted for publication Aug. 7, 1959.

Aided in part by a grant from the Office of Naval Research, Nonr-1866(29).

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