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ARTHUR W. WASE, Ph.D.; JENS CHRISTENSEN, M.D.

AMA Arch Gen Psychiatry 1960;2(2):171-173.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Introduction

Isolation stress is now a recognized important problem involved in simulated and anticipated space flights and presents an urgent contemporary challenge for solution(s). Studies in human isolation are presently an integral part of the basic researches of space medicine and psychiatry.^1-3 The effects of isolation, i.e., stimulus deprivation, are observable as deviant behavior in man¹ and also in laboratory animals.⁴ Barnes⁵ has indicated that modern neuropharmacological agents, especially chlorpromazine, inhibited up to 90% of the abnormal behavior responses developed by rats and mice placed in solitary isolation for 7 to 10 days. Previous studies from these laboratories^6,7 demonstrated that drugs of the ataratic class inhibited, along with other biochemical systems, the turnover of cerebral phospholipids as measured by the incorporation of P³²o-phosphate. The degree of inhibition was generally observed to be related . . . [Full Text PDF of this Article]

Author Affiliations
Philadelphia

Departments of Biological Chemistry and Pharmacology, Hahnemann Medical College of Philadelphia.

Footnotes
Submitted for publication July 16, 1959.

We wish to acknowledge the technical assistance of Mary Joan Comber.

These studies were supported in part by the English Fund of the Hahnemann Medical College and Grant M-1383 from the National Institute of Health, U.S. Public Health Service, Bethesda, Md.

Cellotex is a commercial cellulose derivative useful for heat and sound insulation.

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