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HARRY GOLDENBERG, Ph.D.; VIVIAN FISHMAN, Ph.D.; JOHN WHITTIER, M.D.; WALTER BRINITZER, M.D.

AMA Arch Gen Psychiatry 1960;2(2):221-230.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Introduction

A considerable body of information has appeared in the last three decades dealing with blood and urinary aromatic metabolites in schizophrenia.¹ These studies were provoked, in earlier years, by impressive evidence for an aberrant metabolism of aromatic amino acids in one well-defined mental syndrome (phenylpyruvic oligophrenia). The more recent interest in this subject derives from the discovery of powerful psychotomimetic agents, such as d-lysergic acid diethylamide, which can provoke transient mental symptoms in otherwise normal subjects. The feature common to these agents is the presence of an aromatic chemical structure, either the benzene or the indole nucleus.

Attempts to establish the presence of similar or derived compounds in the body fluids of schizophrenics have not been uniformly successful. McGeer et al.² initially confirmed Sano’s³ reports of excessive indole (indican) excretion in mental disease but later reversed their . . . [Full Text PDF of this Article]

Author Affiliations
New York

From the Department of Biochemistry, Hillside Hospital, Glen Oaks, N.Y. (Drs. Goldenberg and Fishman); the Creedmoor Institute for Psychobiologic Studies, Queens Village (Dr. Whittier), and the Creedmoor State Hospital (Dr. Brinitzer).

Footnotes
Submitted for publication July 24, 1959.

This study was supported by a research grant (M-1305) from the National Institute of Mental Health, U.S. Public Health Service.

Presented in part at the 125th Meeting of the American Association for the Advancement of Science, Washington, D.C., Dec. 30, 1958.

We wish to acknowledge the technical assistance of Victor Bandurco, Grace Crawford, and Susan Drazba (Hillside Hospital), as well as the co-operation of the Male Reception Staff at the Creedmoor State Hospital.

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