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HERBERT SPRINCE, Ph.D.; ENOCH HOUSER, M.S.; DOROTHY JAMESON, B.A.; F. CURTIS DOHAN, M.D.

AMA Arch Gen Psychiatry 1960;2(3):268-270.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Abnormal excretion of urinary indoles has long been implicated in mental illness. This has become well defined in two hereditary diseases with mental symptoms, namely, phenylketonuria¹ and H (Hartnup) disease.² Attempts to relate schizophrenia to indole metabolism have been inconclusive. Recent studies, however, have revealed certain Ehrlich-benzaldehyde-reacting spots, which occur more frequently, or with greater intensity, on paper chromatograms of urine from schizophrenic patients than from those of normal subjects.^3-5 One such spot has been found by several investigators independently. On paper chromatograms sprayed with Ehrlich’s benzaldehyde reagent (EBR) it gives an azure-blue color and is easily located by its characteristic position in relation to urea and indoxylsulfate.^4,5

The purpose of this report is twofold: (1) to describe a method for the differential extraction of indoles from urine, including the above-mentioned spot, and (2) to present results of chromatographing extracts obtained . . . [Full Text PDF of this Article]

Author Affiliations
Philadelphia

From the Laboratory of Research Biochemistry, Veterans Administration Hospital, Coatesville, Pa., and Departments of Psychiatry and Medicine, University of Pennsylvania School of Medicine.

Chief Research Biochemist, Veterans Administration Hospital, Coatesville, Pa.; Research Associate in Psychiatry, University of Pennsylvania School of Medicine, Philadelphia; Visiting Lecturer in Biochemistry, New York Medical College, New York (Dr. Sprince). Research Assistant, U.S. Public Health Service Grant No. M-1015 (C3), University of Pennsylvania (Mr. Houser). Research Technician, Veterans Administration Hospital, Coatesville, Pa. (Miss Jameson). Assistant Professor of Clinical Medicine, University of Pennsylvania School of Medicine; Research Consultant in Metabolic Diseases, Veterans Administration Hospital, Coatesville, Pa. (Dr. Dohan).

Footnotes
Submitted for publication Aug. 14, 1959.

This investigation was aided by Research Grants M-1015 (C2) and (C3) from the National Institute of Mental Health, National Institutes of Health, U.S. Public Health Service.

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