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MARCEL BERTHIAUME, M.D.; JEAN LEDUC, M.D.; ANTOINE D’IORIO, Ph.D.

AMA Arch Gen Psychiatry 1960;2(4):468-469.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Among the various biochemical abnormalities described in schizophrenia, the oxidation of epinephrine has stimulated considerable interest. Hoffer and co-workers^1,2 have suggested that oxidized derivatives of epinephrine, especially adrenochrome and adrenolutin, may be involved in the production of psychotic disorders. In support of this hypothesis, Leach and Heath³ presented data which indicated a significant difference in the rate of epinephrine oxidation by plasma of normal and schizophrenic persons. After the addition of epinephrine to plasma, the formation of an oxidized derivative was found to be more than twice as rapid in the schizophrenic group as in the normal group. These results were interpreted as indicating a qualitative difference in ceruloplasmin or other enzyme systems.

In the present experiments, radioactive epinephrine was added to plasma obtained from normal and psychotic subjects, and the metabolites formed during the incubation were detected by . . . [Full Text PDF of this Article]

Author Affiliations
Montreal

From the Department of Physiology, University of Montreal Faculty of Medicine, and Hôpital St-Jean de Dieu.

Footnotes
Submitted for publication Oct. 13, 1959.

This research has been supported by the Department of National Health and Welfare of Canada through the cooperation of the Department of Public Health of the Province of Quebec (Grant M.H. 604-5-68).

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