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Effects of Triiodothyronine in Schizophrenic PatientsCorrelations of Changes in Basal Metabolism with Urinary Creatine and Cholesterol and Tocopherol Levels in the Blood
B. J. MEYER, M.B., Ph.D.;
B. CENTURY, Ph.D.;
A. C. MEYER, Ph.D.;
M. K. HORWITT, Ph.D.
AMA Arch Gen Psychiatry 1960;2(5):528-533.
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In a previous paper, the effects of triiodothyronine on the psychiatric status, serum copper, basal metabolism, erythrocyte sedimentation rate, and C-reactive protein in schizophrenic subjects were described.1 Changes in serum cholesterol, plasma tocopherol, and urinary creatine-to-creatinine ratio with respect to the basal metabolic rate (B. M. R.) in chronic schizophrenic subjects treated with triiodothyronine are reported here. At present, there is no reasonable evidence to indicate that metabolic data from these subjects would be different from those obtained from nonschizophrenic subjects. Elevated creatine excretion and B. M. R. and decreased creatinine in the urine, as well as corresponding changes in the serum level of these substances, have been observed in cases of hyperthyroidism.2,4 Both serum cholesterol and tocopherol levels are increased in clinical states of hypothyroidism, and there appears to be an indirect relationship between B. M. R. and blood cholesterol.5,6
. . . [Full Text PDF of this Article]
Author Affiliations
Elgin, Ill.
Biochemical Research Laboratory, Elgin State Hospital.
Footnotes
Submitted for publication Nov. 27, 1959.
Supported by grants-in-aid from the Illinois Mental Health Fund and the National Institutes of Health [A-1126(C1)].
Dosage was calculated as content of L-triiodothyronine in the racemic form of triiodothyronine (Trionine) as supplied by Hoffmann-LaRoche, Inc.
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