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George F. Solomon, MD; Mathea Allansmith, MD; Barbara McClellan, BS; Alfred Amkraut, PhD

Arch Gen Psychiatry. 1969;20(3):272-277.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

VARIOUS abnormalities of serum Proteins and autoimmune phenomena have been reported in conjunction with schizophrenic illness.¹ This study reports differences in the major immunoglobulin (yglobulin) classes, IgG, IgA, and IgM, among hospitalized acute, chronic and remitted schizophrenic patients, nonschizophrenic psychiatric patients, and nonmental patient controls.

Background

Elevation of y-globulin^2-8 and of 19S macroglobulin^9,10 has been reported in the sera of acute and chronic schizophrenic patients. Hypermacroglobulinemia was not found in a group of drug-free schizophrenic patients11 nor correlated with illness in monozygotic twins discordant for schizophrenia.¹² Solomon and co-workers found a slight positive correlation between severity of psychotic symptoms and 19S level in chronic schizophrenic patients.¹³ Qualitative as well as quantitative disturbances in electrophoretic serum protein patterns in schizophrenic patients (some (drug-free) have been described including: splitting of ₂globulin, a line superimposed in the gamma . . . [Full Text PDF of this Article]

Author Affiliations
Palo Alto, Calif

From the Department of Psychiatry (Dr. Solomon); the Department of Surgery (Dr. Allansmith and Mrs. McClellan); and the Department of Medical Microbiology (Dr. Amkraut), Stanford University School of Medicine and the Veterans Administration Hospital, (Drs. Solomon and Amkraut) Palo Alto, Calif.

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