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Multivariate Analyses in Manic-Depressive Illness

LCDR Robert T. Rubin, MC, USNR; John E. Overall, PhD

Arch Gen Psychiatry. 1970;22(1):45-57.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THE USE of psychiatric rating scales for quantifying symptoms and signs is a recent methodologic refinement in behavioral-biochemical correlative investigations of psychiatric patients. Small-sample longitudinal studies, wherein the patient acts as his own control, have shown a number of interesting psychochemical and psychoendocrine correlations that were not evident with earlier cross-sectional sampling techniques.^1-8 Also, multivariate analytic methods now permit both the recognition of intra-individual correlations and the generalization of these correlations into group patterns.⁹ In this paper are presented the results of multivariate analyses of changes over time of manifest psychopathology, quantified by a psychiatric rating scale, and multiple urine biochemical measures in manic-depressive patients. This study attempts to exploit the power of multivariate analytic techniques to elucidate the role of biochemical factors in manic-depressive illness.

In earlier reports studies of several biochemical measures in manic-depressive illness . . . [Full Text PDF of this Article]

Author Affiliations
San Diego, Calif; Galveston, Tex

From the Navy Medical Neuropsychiatric Research Unit ,San Diego, Calif, and the Department of Psychiatry, UCLA School of Medicine, Los Angeles (Dr. Rubin), and the Department of Neurology and Psychiatry, University of Texas Medical Branch, Galveston, Tex (Dr. Overall).

Footnotes
Submitted for publication April 21, 1969.

Opinions expressed are those of the authors and are not to be construed as necessarily reflecting the offcial view or endorsement of the Navy Department.

Reprint requests to The Neuropsychiatric Institute, 760 Westwood Plaza, Los Angeles 90024 (Dr. Rubin).

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